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| 肺结核患者血清PGRN，LCN2水平及其与病情严重程度的相关性 |
| Levels of serum PGRN and LCN2 in patients with pulmonary tuberculosis and their correlation with the severity of disease |
| 投稿时间：2024-01-22 修订日期：2024-04-02 |
| DOI： |
| 中文关键词: 颗粒蛋白前体 脂质运载蛋白2 肺结核 病情严重程度 |
| 英文关键词: Progranulin Lipocalin-2 Pulmonary tuberculosis Severity of disease |
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| 中文摘要: |
| 目的:探讨肺结核(PTB)患者血清中颗粒蛋白前体(PGRN)、脂质运载蛋白2(LCN2)水平及其与病情严重程度的相关性。方法:选取2020年2月~2023年2月期间于本院就诊的127例肺结核患者作为研究对象,根据病情严重程度将其分为轻症组(n=78)、和重症组(n=49),另选取同期体检健康者72例作为对照组。采用酶联免疫吸附法测定各组血清PGRN和LCN2水平；Spearman法分析血清PGRN和LCN2水平与Bandim TB评分之间的相关性；多因素Logistic回归分析重症PTB发生的影响因素；绘制受试者工作特征(ROC)曲线分析血清PGRN和LCN2水平对重症PTB的诊断价值。结果:重症组血清PGRN和LCN2水平明显高于轻症组和对照组(P＜0.05)；重症组糖尿病史占比、Bandim TB评分、IL-10、IFN-γ、PCT、CRP水平明显高于轻症组(P＜0.05)；血清PGRN和LCN2水平与Bandim TB评分均呈正相关(rs=0.428、0.420,均P＜0.001)；PGRN(OR=1.576,95%CI=1.112~2.234)和LCN2(OR=2.163,95%CI=1.320~3.545)为重症PTB发生的危险因素(P＜0.05)；血清PGRN和LCN2水平联合诊断重症PTB的曲线下面积(AUC)为0.943,敏感度为91.84%,二者联合优于各自单独诊断(Z二者联合-PGRN=2.327,P=0.020,Z二者联合-LCN2=2.061,P=0.039)。结论:PTB患者血清PGRN和LCN2水平与Bandim TB评分为正相关关系,二者血清水平与患者病情严重程度密切相关。 |
| 英文摘要: |
| Objective: To investigate the levels of progranulin (PGRN) and lipocalin-2 (LCN2) in the serum of patients with pulmonary tuberculosis (PTB) and their correlation with the severity of disease. Methods: From February 2020 to February 2023, 127 pulmonary tuberculosis patients who visited our hospital were regarded as the study subjects. They were separated into mild disease group (n=78) and severe disease group (n=49) based on the severity of disease. Additionally, 72 healthy individuals who underwent physical examination were regarded as the control group. Enzyme-linked immunosorbent assay (ELISA) was applied to determine the levels of serum PGRN and LCN2 in each group; Spearman method was applied to analyze the correlation between serum PGRN and LCN2 levels and Bandim TB score; multivariate logistic regression was applied to analyze the influencing factors of severe PTB occurrence; receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic value of serum PGRN and LCN2 levels for severe PTB. Results: The serum levels of PGRN and LCN2 in the severe group were obviously higher than those in the mild group and control group (P<0.05); the proportion of diabetes history, Bandim TB score, IL-10, IFN-γ, PCT, CRP levels in severe group were obviously higher than those in mild group (P<0.05); the levels of serum PGRN and LCN2 were positively correlated with Bandim TB score (rs=0.428, 0.420, all P<0.001); PGRN (OR=1.576, 95% CI=1.112-2.234) and LCN2 (OR=2.163, 95% CI=1.320-3.545) were risk factors for the occurrence of severe PTB (P<0.05); the area under the curve (AUC) of the combination of serum PGRN and LCN2 levels for diagnosing severe PTB was 0.943, with a sensitivity of 91.84%, the combination of the two was superior to individual diagnosis (Z combination - PGRN=2.327, P=0.020, Z combination - LCN2=2.061, P=0.039). Conclusion: The serum levels of PGRN and LCN2 in PTB patients are positively correlated with Bandim TB score, and their serum levels are closely related to the severity of disease. |
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