| [Abstract] Objective Objective To compare and analyse the differences in HIV viral load, T-lymphocytes and quantitative biochemical indicators between syphilitic HIV-infected patients and HIV-infected patients. Methods In this project, a total of 107 patients (51 patients with syphilis combined with HIV infection and 56 patients with simple HIV infection) were enrolled in our compassionate outpatient clinic in a retrospective study, blood biochemistry, quantitative biochemistry, T-cell counts, HIV viral load and other variables were accurately recorded, inclusion and exclusion criteria were set in accordance with the 2022 edition of the Chinese Syphilis Clinical Guidelines and Chinese HIV Clinical Guidelines, and qualitative categorical variables were analysed with the use of a chi-square test. Qualitative categorical variables were analysed using the chi-square test, while quantitative variables were analysed using the Mann-Whitney test and binary logistic regression to analyse abnormalities affecting CD4+ T and HIV RNA; p<0.05 was used as the criterion for statistical difference. Results There were no statistically significant differences in T-lymphocyte counts (CD4+, CD3+, CD8+ markers), CD4+/CD8+ ratios, and HIV RNA copy numbers between the syphilis-combined HIV-infected group and the HIV-infected group alone. Conclusion The presence or absence of co-infection with spirochetes of syphilis in HIV-infected patients does not affect their HIV RNA copies and T-lymphocyte counts, therefore, in order to prolong the time for HIV-infected patients to move from the acute phase to the clinical AIDS phase, targeted antiretroviral therapy in the early stages of syphilis should be intensified and highly effective prophylactic tools should be further developed. |