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| 长链非编码RNAs在抗病毒固有免疫中研究进展 |
| Advances of long non-coding RNAs in antiviral innate immunity |
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| DOI：10.3969/j.issn.1007-8134.2020.05.002 |
| 中文关键词: 长链非编码RNAs 固有免疫 竞争性内源RNAs I型干扰素 炎症反应 |
| 英文关键词: long non-coding RNAs innate immunity ceRNAs type I IFN inflammation |
| 基金项目:国家自然科学基金（81873871） |
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| 中文摘要: |
| 长链非编码RNAs（long non-coding RNAs, lncRNAs）作为一类重要的调控分子，在表观遗传学、转录及转录后等多水平参与免疫反应调控。在抗病毒固有免疫反应中，lncRNAs主要通过与蛋白质、DNA、微小RNA、信使RNA等互作来发挥调节作用；与此同时，病毒亦可通过自身lncRNAs作用于宿主参与免疫逃逸。本文概括了lncRNAs在调控抗病毒固有免疫中的重要作用和相关机制，以及lncRNAs在宿主-病毒互作中免疫逃逸等最新研究进展，以期对病毒感染性疾病提供新的研究思路和诊疗方法。 |
| 英文摘要: |
| Long non-coding RNAs (lncRNAs) are critical regulators and modulate immune response epigenetically, transcriptionally and post-transcriptionally. In antiviral innate immunity, lncRNAs mainly exert regulation effect through interaction with proteins, DNAs, miRNAs, mRNAs and so on. Meanwhile, viruses are involved in the immune evasion by their own lncRNAs. This review summarizes the functions and related mechanism of lncRNAs in regulation of innate immune responses and recent advances of lncRNAs mediating immune evasion in the host-viruses interaction, so as to provide a new direction for the studies and therapeutic strategies of viral infectious diseases. |
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